STOmics (Spatial TranscriptOmics) is a revolutionary technology that integrates spatial resolution with gene expression profiling, enabling researchers to visualize where and how genes are expressed directly in tissue sections. Unlike traditional transcriptomics, which loses spatial information during sample processing, STOmics captures the spatial context of each transcript, offering unprecedented insights into the architecture and function of tissues at the molecular level. Read more
Keywords: #Spatial-Transcriptomics, #STOmics, # gene-expression, #spatial-resolution, # tissue-analysis, # single-cell RNA-seq, # spatial-biology
The human body is a complex, highly organized structure. Understanding how genes behave in their native spatial environments is crucial for:
- Mapping the cellular microenvironment
- Uncovering mechanisms of development and disease
- Discovering spatial biomarkers in cancer, neurology, and immunology
- Advancing precision medicine
STOmics enables scientists to go beyond single-cell sequencing by adding spatial information, transforming how we study tissues and organs.
The STOmics workflow typically includes:
- Tissue sectioning and fixation
- Barcoded chip hybridization
- In situ cDNA synthesis and sequencing
- Data analysis with spatial mapping
BGI’s STOmics technology uses high-density chips with millions of barcoded capture spots. These spatial barcodes link every RNA molecule to its precise location within the tissue. After sequencing, powerful bioinformatics tools reconstruct a 3D map of gene expression across the sample.
Technical Advantage: STOmics provides subcellular resolution, allowing detailed analysis of tissue heterogeneity, cell-cell interactions, and gene expression gradients.
STOmics is transforming multiple fields, including:
Neuroscience
- Study brain tissue architecture
- Map neuron-glia interactions
- Investigate neurodegenerative disease progression
Cancer Biology
- Identify tumor microenvironments
- Explore intratumoral heterogeneity
- Discover spatial gene signatures for targeted therapies
Immunology
- Visualize immune cell infiltration
- Understand tissue-specific immune responses
- Decode cytokine signaling networks
Developmental Biology
- Track tissue formation
- Understand lineage specification
- Uncover spatially regulated developmental genes
Why Choose BGI for STOmics?
At BGI, we combine cutting-edge STOmics platforms with deep expertise in genomics and bioinformatics. Our services offer:
- Ultra-high resolution (subcellular level)
- Flexible sample compatibility
- Robust bioinformatics support
- Comprehensive reports ready for publication
Whether you're studying complex disease mechanisms or developing new biomarkers, BGI's STOmics service empowers your research with unparalleled spatial insights.
Get Started with STOmics Today
Join the spatial biology revolution with BGI. Our team is here to support your research from sample submission to data interpretation.
Contact us now to learn how STOmics can elevate your project.
🌐 www.bgi-international.com/contactus
Explore the spatial dimension of biology. Discover more with BGI STOmics.